Scientific Advisory Board

Chairman

Robert Kloner, M.D.

Robert Kloner, M.D., Ph.D.

Robert A. Kloner, MD, PhD, is Professor of Medicine, in the Cardiovascular Division, Keck School of Medicine, at the University of Southern California, in Los Angeles. He is also Director of Research at the Heart Institute of Good Samaritan Hospital in Los Angeles and attending cardiologist at Los Angeles County/University of Southern California Medical Center. Dr. Kloner received his MD in the Honors Program in Medical Education and PhD degrees from Northwestern University Medical School in Chicago and is a member of Alpha Omega Alpha honor society. He completed internship and residency in internal medicine at Peter Bent Brigham Hospital in Boston, Massachusetts. Additional training included clinical and research fellowships in medicine and cardiology at Harvard Medical School and Brigham and Women’s Hospital. He served as Assistant and then Associate Professor of Medicine at Harvard Medical School and as an attending cardiologist at Brigham and Women’s Hospital. There he received an Established Investigator Award of the American Heart Association. Dr. Kloner is a fellow of the American College of Cardiology, an Inaugural Fellow of the Council on Basic Cardiovascular Sciences of the AHA, and was elected to the American Society of Clinical Investigation. Among Dr. Kloner’s major research interests are cardiac cell transplantation, protection of ischemic myocardium, development of therapies for limiting myocardial infarct size, cardiac function following coronary artery occlusion, the effect of toxins on the heart, including the effect of air pollution on the heart, preventative cardiology, hypertension, and PDE5 inhibition. He has participated in studies funded by the National Institutes of Health on cardiac cell transplantation, doxorubicin cardiomyopathy, functional analysis of cardiac grafts, and stem cells. He has served on the NIH Cardiovascular Study Section A and has participated in a number of NIH Workshops. A frequent contributor to the medical and scientific press, Dr. Kloner has contributed over 560 original papers in peer-reviewed journals; over 210 chapters or monographs and over 445 abstracts. Dr. Kloner is the author and editor of 18 medical texts including: Ischemic Preconditioning , Cardiovascular Trials Reviews (10 editions), and The Guide to Cardiology (3 editions). Among his editorial responsibilities, Dr. Kloner served as associate editor of the Journal of Cardiovascular Pharmacology and Therapeutics from 1996 to 2009 and in 2009 became the editor-in-chief. He is an associate editor of the International Journal of Impotence Research, and is Guest Editor of Circulation. He is on the editorial boards of American Journal of Cardiology, Heart, Basic Research in Cardiology, Regenerative Medicine, and Congestive Heart Failure. Among his many career distinctions, Dr. Kloner has been listed in Who’s Who in America and The Best Doctors in America and in 2002 was identified by the Institute for Scientific Information as ISI Highly cited.com; one of the worlds’s most highly cited scientific authors. Dr. Kloner is a frequent lecturer at major scientific symposia including the Scientific Sessions of the American Heart Association, American College of Cardiology, and Transcatheter Cardiovascular Therapeutics Meetings, and he has lectured at most major academic medical centers in the United States. Dr. Kloner serves as Chairman of the IC Therapeutics scientific advisory board.

 


Charles E. Murry, M.D., Ph.D

Charles E. Murry, M.D., Ph.D

 

Charles (Chuck) Murry is Professor of Pathology and Bioengineering at the University of Washington in Seattle. Murry is Director of the Center for Cardiovascular Biology and Co-Director of the newly formed Institute for Stem Cell and Regenerative Medicine. He obtained his Ph.D. and M.D. from Duke University and did a fellowship in vascular biology at the University of Washington under Stephen M. Schwartz, M.D., Ph.D. Of particular note, Dr. Murry is widely recognized as the first to introduce the concept of ischemic preconditioning, in which repetitive brief periods of ischemia protected the myocardium from a subsequent longer ischemic insult (Circulation 74: 1124-1136, 1986). His awards include a Burroughs Wellcome Career Award in Biomedical Sciences in 1996, the Presidential Early Career Award in Science and Engineering in 2000 and 3 awards for outstanding teaching in basic sciences. The Murry laboratory’s research focuses on myocardial infarction and strategies to enhance the heart’s lack of intrinsic regenerative ability. Active projects explore the molecular mechanisms that underlie the heart's normal wound healing processes and in developing molecular and cell-based approaches to improve infarct repair, with a special emphasis on adult and pluripotent stem cells. They are a multidisciplinary group, doing basic work in molecular biology and regulation of gene expression, cell biology, tissue engineering, animal models of disease and analyses of human tissues.

 


Harvey Hecht, M.D.

Harvey Hecht, M.D.

 

Dr. Hecht is an expert in cardiac imaging and preventive cardiology, and is the author of more than 100 publications in peer reviewed journals. He completed his internship and residency in Internal Medicine at the Albert Einstein College of Medicine and Mount Sinai Hospital (NY) and a fellowship in Cardiology at Beth Israel Hospital, Harvard Medical School. His academic appointments have included Instructor in Medicine at Harvard Medical School, Assistant Professor at UCLA, Associate Professor at the University of Southern California and University of California, San Francisco, and Clinical Professor of Medicine at the Albert Einstein College of Medicine . A graduate of Columbia College and the Albert Einstein College of Medicine, Dr. Hecht is board certified in Internal Medicine and Cardiovascular Diseases, and is a Fellow of the American College of Cardiology. He is a consultant to the editors of numerous cardiovascular publications, including the Journal of the American College of Cardiology, American Journal of Cardiology, Circulation, American Heart Journal, Journal of Invasive Cardiology, and the Journal of the American Society of Echocardiography. He is one of the founders of, and was the first President of the Society of Atherosclerosis Imaging, as well as one of the founders of the Society of Cardiovascular Computed Tomography. He has been involved in early stage development of several startup companies in the medical arena which have had successful IPO’s.

 


Stanley Kleis, Ph.D.

Stanley Kleis, Ph.D.

Dr. Kleis is an Associate Professor of Mechanical Engineering at the University of Houston. Dr. Kleis, who holds a Ph.D. from Michigan State University, has worked with NASA for nearly 20 years to enhance the functionality of its bioreactors. He was principle investigator on two space shuttle flight experiments and received one of NASA’s highest honors, the Public Service Medal. He has expertise in fluid mechanics and heat and mass transport with emphasis on experimental measurements and applied computational fluid dynamics.

 


Ralph Metcalfe, Ph.D.

Ralph Metcalfe, Ph.D.

Dr. Metcalfe received his B.S. in Mathematics from the University of Washington, his M. S. in mathematics from M. I. T. and his PhD in applied mathematics from M. I. T. with Professor Steven Orszag. After completing his graduate studies, he worked for 12 years as a research scientist at Flow Research Company in Seattle, Washington. In 1987, he joined the faculty at the University of Houston where he is presently professor of mechanical engineering and mathematics.


Recently, his work has focused on numerical simulations of blood flow in normal and diseased carotid arteries to investigate the role of fluid dynamic parameters such as wall shear stress and vortex generation on the formation of atherosclerotic lesions. In conjunction with surgeons at the Texas Heart Institute, Dr. Metcalfe has also investigated numerically the fluid dynamical consequences of implantation of a new type of Ventricular Assist Device.


Recently, Dr. Metcalfe was appointed chair of the National Institutes of Health Cardiovascular Devices Study Section.


 


Hirofumi Tanaka, Ph.D.

Hirofumi Tanaka, Ph.D.

Dr. Tanaka is an associate professor and the director of the Cardiovascular Aging Research Laboratory at the University of Texas at Austin. He received a B.A. in physical education at the International Martial Arts University in Japan, a M.S. in Bioenergetics from Ball State University, and a Ph.D. in applied physiology from the University of Tennessee. Dr. Tanaka’s research interests revolve around preventive cardiology and preventive gerontology, with primary research interests involving habitual exercise, aging, and vascular function. He has published over 100 original research articles. He is an elected fellow of various professional organizations including the American Heart Association, the American College of Sports Medicine, the Gerontological Society of America, and the Society for Geriatric Cardiology.